Novequin Pet 90g (Arthur Andrew Medical)(Digestive Probiotic Formula)

Triple Magnesium Power for Everyday Wellness ✔️ 3 Forms of Highly Bioavailable Magnesium✔️ Nutrient Support for Mood & Stress Balance✔️ Mineral Support for Bone, Joint & Muscle Function Mag3Ultra® combines three advanced, bioavailable forms of magnesium—Sucrosomial Magnesium Oxide, Magnesium Taurate, and Magnesium Bisglycinate—with Potassium Gluconate and Ascorbyl Palmitate (fat-soluble Vitamin C) to support a variety of important physiological processes. Designed to complement your daily routine, Mag3Ultra® offers a comprehensive mineral profile in a thoughtfully formulated blend. How It Works Many magnesium supplements are associated with gastrointestinal discomfort due to low absorption. Mag3Ultra® features Sucrosomial Magnesium, a delivery system that encapsulates magnesium in a sucrosome matrix—helping it pass through the stomach more comfortably and reach the intestines for better uptake. Functional Benefits Well-Tolerated Magnesium The sucrosomial delivery system helps magnesium travel through the digestive tract more gently compared to some conventional forms. Structural Support Magnesium is involved in numerous cellular functions related to the body’s framework and structure. The combination of minerals in Mag3Ultra® is designed to complement these physiological roles. Muscle Function Magnesium and potassium contribute to normal muscle activity. This formula is developed with ingredients known to play a role in muscle-related pathways. Everyday Balance Magnesium participates in enzyme activity and cellular signalling processes. Mag3Ultra® provides forms of magnesium that are bioavailable and well-tolerated to support daily nutritional needs. Ingredients Sucrosomial Magnesium OxideA form of magnesium encapsulated in a lipid matrix to support absorption and digestive comfort. Magnesium TaurateCombines magnesium with taurine, an amino acid-like compound. Magnesium BisglycinateA chelated form of magnesium, known for its solubility and mild profile. Potassium GluconateA source of potassium that contributes to fluid balance and normal muscle function. Ascorbyl PalmitateA fat-soluble form of Vitamin C, often used for its antioxidant properties and stability in formulations. Suggested Use General Use: Take 1–3 capsules per day, or as directed by a healthcare practitioner. Higher Intake: Take 4–6 capsules per day, in divided doses, or as directed by a healthcare practitioner. Always consult your healthcare provider for guidance. This product is not intended to diagnose, treat, cure, or prevent any disease. If you are pregnant, breastfeeding, taking medication, or have a medical condition, consult your healthcare professional before use. Keep out of reach of children. Do not exceed the recommended daily dose. FAQs Is Sucrosomial Magnesium different from regular magnesium oxide?Yes, Sucrosomial Magnesium differs significantly from regular magnesium oxide. While magnesium oxide is commonly found in supplements due to its high elemental magnesium content (around 61%), Sucrosomial Magnesium utilizes magnesium oxide encapsulated within a sucrosome for improved digestive tolerability and absorption. Despite containing a lower percentage of elemental magnesium (around 31%), Sucrosomial Magnesium has been shown to be more bioavailable than magnesium oxide alone. High elemental magnesium content in magnesium oxide can be harsh on the digestive tract, making the Sucrosomial form a preferable option. Is Mag3Ultra missing calcium?Dietary calcium deficiency is a major problem globally. However, it is not a lack of calcium that creates this deficiency, proper calcium absorption and utilization is the problem. Mag3Ultra supports proper magnesium levels so that calcium is utilized properly. For the most optimal use of calcium, we recommend taking Mag3Ultra with Vitamin D3, and Vitamin K2. The latter two vitamins can be found in KD Ultra, our premier blend of vegan Vitamin D3 and Vitamin K2. When is the best time to take Mag3Ultra?The best time to take Mag3Ultra is with meals to minimize the risk of digestive issues and maximize absorption. If you don't experience the desired benefits with meals, you can try taking it between meals or before bed after ensuring your body tolerates magnesium well. Mag3Ultra contains three highly tolerated forms of magnesium, but starting with meals is advisable to assess your body's response to the product. Is Mag3Ultra Kosher?The product is certified Kosher by Star-K, and a copy of the certification is available upon request. Is Mag3Ultra vegan friendly?The formula is vegan in accordance with the guidelines of the American Vegetarian Association.

Neprinol is a revolutionary blend of systemic enzymes and antioxidants specially formulated to support healthy circulatory and immune function.* Neprinol's vegetarian enzyme blend tested to be more than 500% more fibrinolytic than the leading animal-based enzyme formulation.† Neprinol's blend of systemic enzymes are similar to digestive enzymes, but are primarily used throughout the bloodstream rather than the gastrointestinal tract. Neprinol supports healthy levels of Endogenous Blood Particles or EBP’s.* EBP’s can be decayed cells, fibrin, fatty proteins, and other unwanted materials that normally accumulate in the blood.* Systemic enzymes like those in Neprinol support the body’s natural purification of these EBP’s, as well as maintaining healthy liver function and healthy inflammatory levels. Sustaining a healthy level of EBP’s is also beneficial for maintaining optimal immune and circulatory function.* Efficacy is of utmost importance to doctors and patients alike and Neprinol addresses this concern with a proven potency that can be utilized by healthcare professionals. Neprinol’s enzymes are remarkably different from typical animal derived systemic enzymes, which are sometimes derived from pork and cow sources. The enzymes in Neprinol are a combination of vegetarian and selectively potent microbial strains. Although these ingredients are extremely potent, they are well tolerated in the body. Neprinol can be recommended for both clinical use and therapeutic applications. Recent medical breakthroughs, including clinical research performed on Neprinol, have led to the application of systemic enzymes to support the digestion of debris from the cardiovascular system.* This provides for a reduced level of EBP’s, which can support healthy inflammatory responses and their relation to joint discomfort and stiffness.* Healthy, reduced-EBP blood sustains relatively normal blood clotting factors as well. Enzymes support a healthy immune system and may support the repair damaged tissues, and even more remarkably, they require smaller doses over time to maintain their efficacy.* Systemic enzyme products have been and continue to be under-utilized dietary aids, despite the fact that their use dates back further than most supplements. As we age, the need for enzymes increases significantly. Enzymes are essential to maintain a strong immune system, healthy joints, good circulation and overall balanced reaction to injury.* All of the enzyme components in Neprinol are derived from all-vegetarian sources, which by nature are biochemically more effective than those produced by the human body.* Supplementing with Neprinol, can replace these lost and valuable enzymes. Combined with proper diet and exercise they may drastically reduce vulnerability to a wide range of health concerns.* †Based on 3rd party fibrinolytic assay testing. Fibrin Defense Fibrin is a protein formed in the human body responsible for scar tissue and thrombus formation. Neprinol contains a blend of fibrinolytic (fibrin degrading) enzymes that specifically address fibrin levels in the body. Our bodies normally secrete sufficient levels of plasmin, an important enzyme present in the blood that degrades many blood plasma proteins and blood clots. Plasmin, our own natural blood thinner, is responsible for maintaining normal blood solvency by removing unnecessary accumulated protein. The normal process of removing excessive fibrin can be enhanced by introducing fibrinolytic enzymes like those found in Neprinol. Fibrinogen Over-Production Hyper-coagulation & Fibrin Defense Enzymes can be thought of as proteins on a mission. And when it comes to improving your health, one of the most potent targets an enzyme can seek and destroy is a fibrous protein called fibrin. Neprinol contains a powerful combination of fibrin-dissolving enzymes like serrapeptase, nattokinase and bromelain, as well as other natural ingredients. That is why it is known as Neprinol AFD – Advanced Fibrin Defense®. But to understand why the body needs help defending itself against fibrin you first need to understand a bit more about the protein itself. Fibrin Fibrin is an insoluble protein that plays a major role in the formation of blood clots and scar tissue. During the blood clotting process, the soluble protein fibrinogen converts into insoluble fibrin, which is then laid down inside the damaged blood vessel. The fibrin strands then assemble into a net-like gel that hardens and captures all of the materials necessary to patch the damaged vessel. This is the structural framework of a blood clot. Obviously, fibrin plays a vital role in the healing process; however, when there is fibrin overproduction, it can lead to the formation of dangerous and unnecessary blood clots in the body [1]. One factor that can lead to excessive fibrin is ageing. As we age, the concentration of fibrinogen increases in our blood [2]. High levels of fibrinogen increases fibrin production, and as fibrin begins to accumulate in the blood vessels it generally leads to the formation of blood clots [3]. Healthy individuals usually have sufficient levels of plasmin, an enzyme that breaks up fibrin blood clots. Unfortunately plasmin production slows down as we get older so the normal process of removing excess fibrin is reduced. The result of this can be cardiovascular disease, heart attacks, strokes, pulmonary emboli, deep vein thrombosis (DVT) and other related disorders [4-8]. Neprinol Research has shown that protein-dissolving enzymes like those found in Neprinol can slow the production of fibrin and enhance its removal from the body [1]. Neprinol's blend of enzymes generally tests well above 50,000 FU per gram, which means that 50,000 units of fibrin are broken down by each gram of Neprinol powder. Of the enzymes contained in this formula perhaps the most significant is nattokinase, which has been shown to be four times more powerful than our body's own plasmin at breaking down blood clots [9]. Nattokinase Nattokinase is an enzyme extracted from natto, a fermented soybean 'cheese' that is popular in Japan [10]. The ability of nattokinase to breakdown fibrin has been tested in more than 12 studies [11], and nattokinase has been shown to be the most potent fibrin-degrading enzyme out of more than 200 foods tested [3]. Researchers have found that nattokinase works much in the same way as plasmin [3], which means thatnattokinase literally dissolves fibrin, whether it is holding together blood clots or is part of scar tissue [12]. However, nattokinase also blocks the activity of plasminogen activator inhibitor 1 (PAI-1), which boosts its fibrin-destroying capabilities even more [9,13]. Plasminogen is made into plasmin, the body's fibrin-dissolving enzyme. However, the conversion process is inactivated by PAI-1. This is why high levels of PAI-1 reduce fibrin breakdown and removal [14]. Nattokinase increases fibrin breakdown by blocking PAI-1 so that more plasmin is produced. Because of this nattokinase is not only able to stop dangerous blood clots from developing but also helps dissolve any clots that have already formed. As a result, oral nattokinase supplements are recommended for preventing cardiovascular disease [15]. Nattokinase has also been shown to reduce the risk of deep vein thrombosis (DVT) in high-risk patients in combination with pycnogenol[16]. Bromelain Bromelain is an extract from pineapple that contains a number of fibrin-degrading enzymes [17,18], as well as enzymes that enhance this fibrin-dissolving action [19]. Bromelain was shown to increase the conversion of plasminogen into plasmin [20-22]. It has also been shown to prevent the conversion of fibrinogen to fibrin [17]. However, unlike nattokinase, bromelain is not able to dissolve fibrin clumps that have already formed [17]. Because a high percentage of ingested bromelain is absorbed intact into the bloodstream, protein- and fibrin-degrading activity in the blood can be increased for hours after taking it [23]. Two large-scale trials in patients with heart problems showed that bromelain could almost completely eliminate thrombosis [24]. Serrapeptase Serrapeptase is another important component of Neprinol's advanced fibrin defense. Serrapeptase is a protein-degrading enzyme isolated from the silk worm [25]. It has significant anti-inflammatory and fibrin-removal activity [26], which makes it ideal for preventing blood clot formation associated with cardiovascular disease. Other Diseases Linked to Fibrin The buildup of excess fibrin in the body can cause more health problems than just blood clots. Fibrin has also been linked to a number of chronic and progressive diseases like multiple sclerosis [27,28] and asthma [29]. As a result, Neprinol's fibrin-degrading enzymes could prove to be a good treatment option [1,30]. Breaking down fibrin using enzymes may also help a number of conditions that are difficult to treat, such as Peyronie’s disease, Dupuytren’s contracture and Ledderhose’s disease. All of these conditions are characterized by a loss of tissue elasticity, which leads to tissue tearing, then bleeding, clot formation and fibrin deposition. Over time, taking fibrin-degrading enzymes may reduce the amount of scar tissue built up in locations where there has been repeated damage and bleeding [1]. Finally, using enzymes to dissolve fibrin may also play a role in cancer prevention and treatment. Cancer cells often are surrounded by a fibrin coating [31]. Researchers think that the fibrin may provide a type of camouflage for these abnormal cells, allowing them to escape being destroyed by the immune system. It is possible that by removing this fibrin coating, the body could detect cancer cells and destroy them before they are able to gain a foothold in the body. Advanced Fibrin Defense As you can see, excess fibrin can wreak havoc on our bodies, especially as we get older and our natural production of enzymes decreases. However, Neprinol provides a combination of superior fibrin-active enzymes designed to keep fibrin levels in check. Neprinol is an excellent choice for anyone suffering from, or hoping to prevent, the harmful effects of excess fibrin. Suggested Use Directions: Take 1 to 4 capsules with 8 oz of water between meals or as directed by your healthcare practitioner. For therapeutic results, take 3 or 4 capsules three times daily. Warning: Do not take Neprinol without the consent of your physician if you are taking anti-coagulants or if you are pregnant or nursing. Is Neprinol safe? No serious or adverse side effects have been reported from taking systemic enzymes such as Neprinol. Clinical studies have shown that even extremely large doses of these enzymes are not toxic. If you are taking blood-thinning medication, you should consult with your physician before taking Neprinol. When is the best time to take Neprinol? For best results, take the product atleast one hour prior to eating and/or two hours after a meal. Can I take Neprinol with other supplements? Neprinol can be used safely with other dietary supplements. How long does it take for Neprinol to work? Although every person is different, some have reported feeling the effects of systemic enzymes in as little as 45 minutes. For therapeutic regimens, the progression may be slow for some and quicker for others. Typically, supplementing the product for a minimum of a month's time is recommended, with the best results occurring anywhere from one to three months thereafter. Supplement Facts Nattokinase A fibrinolytic enzyme derived from the fermentation of Bacillus subtilis that can help to maintain normal blood viscosity and normal cardiovascular health.SerrapeptaseA proteolytic (protein digesting) enzyme with potent fibrinolytic activity can support healthy fibrin concentrations. It has been clinically shown to support healthy mucus viscosity and promote normal recovery after physical stress.LipaseUsed systemically, this enzyme digests fats in the blood and can help convert fats into fatty acids, which may be expressed or retained as energy.ProteaseA proteolytic enzyme that, when present in blood serum, plays an important role in the blood’s health. It can also help support a healthy immune system and improve circulatory health.AmlaDerived from Indian Gooseberry, amla contains tannic acid, glucose, cellulose, and calcium. Amla helps maintain pH balance, and has a high concentration of naturally derived vitamin C.PapainA proteolytic enzyme derived from papaya that can promote normal healing and inflammation from overexertion.RutinA flavonoid (plant pigment) that helps to maintain strong capillaries and connective tissue, as well as healthy blood vessels.CoQ10Decreases the proliferation of free radicals, supporting a healthy immune system. CoQ10 helps promote maintenance of normal cardiovascular function and is a coenzyme that is essential for enzymes to function in the body.MagnesiumPromotes a healthy cardiovascular system, and is essential for cell repair, hormones, and a regular heartbeat. Magnesium also helps reduce the effects of increased stress. Other Ingredients: Cellulose (Acid Amor™ capsules) Neprinol™ is free of dairy, gluten, and soy allergens. Contains no artificial colors or preservatives. Keep out of reach of children. Store in a cool, dry place with lid tightly closed. WARNING: Do not take this product without the consent of your physician if you are currently taking anti-coagulants or if you are pregnant or nursing. Frequently Asked Questions What is Neprinol? Neprinol is a proprietary combination of Serrapeptase, Nattokinase, Protease, Lipase, Bromelain, Papain, Rutin, Amla and other proteolytic enzymes that are specially formulated to assist your body's defense of the damaging effects of fibrin. Neprinol has been used to strengthen the immune and circulatory systems, maintain a healthy inflammatory response and to support the body's natural recovery process.* What are Enzymes? Enzymes are proteins (or protein-based molecules) that act as catalysts in biochemical reactions. Every enzyme has a specific reactant known as a substrate, which can be thought of like a lock and a key. Only a specific enzyme (or key) will react (or unlock) its substrate. This is the reason why enzymes are unable to break down necessary and vital tissue, as they only react with certain harmful proteins in the body. What are "Systemic Enzymes"? When enzymes are introduced into the bloodstream, they work “systemically”, or throughout the entire body. Taking enzymes on an empty stomach allows them to work systemically since they will bypass the upper digestive process and enter the bloodstream through the intestine. Systemic enzymes are similar to digestive enzymes, though certain enzymes are better designed for systemic activity as opposed to digestion due to the materials they react with, such as Serrapeptase and Nattokinase. These two enzymes are very efficient with the breakdown of a particular substance known as Fibrin. What is Fibrin? Fibrin is a protein substance naturally formed in the human body that plays a significant role in our health and general well-being. Fibrin is responsible for scar tissue formation, and is produced as a reaction to injury. Our bodies naturally maintain healthy fibrin levels with enzymes (principally plasmin) whose role is to attack and break down any excessive fibrin. As fibrin builds up in the body, it can cause many unhealthy conditions. Why Neprinol? As we age, our natural enzyme production decreases while the need for these enzymes is of increasing importance. Supplementing these valuable enzymes can combat enzyme deficiencies that can lead to a wide variety of health concerns. Healthy levels of these enzymes can assist the body in maintaining a healthy immune system, healthy joints, proper circulation and an overall balanced reaction to injury. How Does Neprinol Work? By supplementing and replenishing the body's diminishing enzymes, Neprinol provides one of our most essential and basic biochemical needs. It supplements the body's natural fibrinolytic enzyme levels thereby helping to maintain healthy fibrin levels: an underlying causative agent for many unhealthy conditions in the body.* Is Neprinol Enteric Coated? Enteric coatings are designed to protect enzymes and other supplements from stomach acid. Plastic-like chemicals known as phthalates are often used in this coating process. Phthalates are actually banned in children's toys in Europe and Mexico, so why would we ever include these in our formulas? Arthur Andrew Medical has instead developed an all-natural, chemical-free Acid Armor capsule. These capsules are comprised of an extra-thick layer of cellulose (vegetable capsules) with a micro threaded locking mechanism to prevent leaking. Acid Armor capsules have been designed to delay the release of the capsule's contents for up to an hour without the use of potentially harmful chemicals. Is Neprinol Safe? No serious or adverse side effects have been reported from taking systemic enzymes such as Neprinol*. Clinical studies have shown that even extremely large doses of these enzymes are not toxic. If you are taking blood-thinning medication, you should consult with your physician before taking Neprinol. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Neprinol contains Pharmaceutical-grade ingredients. The product is provided exclusively through licensed health-care practitioners and supplementation outlet stores. Neprinol is 100% natural and contains no animal derivatives. References: Meletis CD, Barker JE. Therapeutic enzymes: using the body's helpers as healers. Alt Comp Ther. 2005;74-77. Meade TW. Fibrinogen and cardiovascular disease. J Clin Pathol. 1997;50:13-15. Milner M, Makise K. Natto and its Active Ingredient Nattokinase: a potent and safe thrombolytic agent. Alt Comp Therap. 2002;8(3):157-164. Koenig W. Fibrin(ogen) in cardiovascular disease: an update. Thromb Haemost. 2003;89:601-609. Lefevre M, Kris-Etherton PM, Zhao G, Tracy RP. Dietary fatty acids, hemostasis, and cardiovascular disease risk. J Am Diet Assoc. 2004;104:410-419. Kannel WB. Overview of hemostatic factors involved in atherosclerotic cardiovascular disease.Lipids. 2005;40:1215-1220. Eidelman RS, Hennekens CH. Fibrinogen: a predictor of stroke and marker of atherosclerosis.Eur Heart J. 2003;24:499-500. Nesheim M. Myocardial infarction and the balance between fibrin deposition and removal. Ital Heart J. 2001;2:641-645. Fujita M, Hong K, Ito Y, et al. Thrombolytic effect of nattokinase on a chemically induced thrombosis model in rat. Biol Pharm Bull. 1995;18:1387-1391. Sumi H, Hamada H, Tsushima H, Mihara H, Muraki H. A novel fibrinolytic enzyme (nattokinase) in the vegetable cheese Natto; a typical and popular soybean food in the Japanese diet.Experientia. 1987;43:1110-1111. Pais E, Alexy T, Holsworth RE Jr, Meise HJ. Effects of nattokinase, a pro-fibrinolytic enzyme, on red blood cell aggregation and whole blood viscosity. Clin Hemorheol Microcirc. 2006;35:139-142. Sumi H, Hamada H, Nakanishi K, Hiratani H. Enhancement of the fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol. 1990;84:139-143. Suzuki Y, Kondo K, Matsumoto Y, et al. Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci. 2003;73:1289-1298. Hamsten A, de Faire U, Walldius G, et al. Plasminogen activator inhibitor in plasma: risk factor for recurrent myocardial infarction.Lancet. 1987;2:3-9. Hsia C-H, Shen M-C, Lin J-S, et al. Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects. Nutr Res. 2009;29:190-196. Cesarone MR, Belcaro G, Nicolaides AN, et al. Prevention of venous thrombosis in long-haul flights with Flite Tabs: The LONFLIT-FLITE randomized, controlled trial. Angiology. 2003;54:531-539. Maurer HR. Bromelain: biochemistry, pharmacology and medical use. Cell Mol Life Sci.2001;58:1234-1245. Pirotta F, de Giuli-Morghen C. Bromelain: antiinflammatory and serum fibrinolytic activity after oral administration in the rat. Drugs Exp Clin Res. 1978;4:1-20. Ako H, Cheung AH, Matsuura PK. Isolation of a fibrinolysis enzyme activator from commercial bromelain. Arch Int Pharmacodyn Ther. 1981;254(1):157-167. Maurer HR, Eckert K, Grabowska E, Eschmann K. Use of bromelain proteases for inhibiting blood coagulation. Patent WO PCT/EP 98/04406. 2000. De-Giuli M, Pirotta F. Bromelain, interaction with some protease inhibitor and rabbit specific antiserum. Drugs Exp Clin Res. 1978;4:21-23. Smyth RD, Brennan R, Martin GJ. Systemic biochemical changes following the oral administration of a proteolytic enzyme, bromelain. Arch Int Pharmacodyn. 1962;136:230-236. Taussig SJ. The mechanism of the physiological action of bromelain. Med Hypotheses. 1980;6(1):99-104. Felton GE. Fibrinolytic and antithrombotic action of bromelain may eliminate thrombosis in heart patients. Med Hypotheses. 1980;6(1):1123-1133. Sandhya KV, Devi SG, Mathew ST. Quantitation of serrapeptase in formulations by UV method in the microplate format. Curr Drug Deliv. 2008;5(4):303-305. Mazzone A, Catalani M, Costanzo M, et al. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: A multicentre, doubleblind, randomized trial versus placebo. J Int Med Res. 1990;18:379-388. Sobel RA, Mitchell ME. Fibronectin in multiple sclerosis lesions. Am J Pathol.1989;135:161-168. Gveric D, Hanemaaijer R, Newcombe J, van Lent NA, Sier CF, Cuzner ML. Plasminogen activators in multiple sclerosis lesions: implications for the inflammatory response and axonal damage. Brain.2001;124(Pt 10):1978-1988. Pretorius E, Oberholzer HM. Ultrastructural changes of platelets and fibrin networks in human asthma: a qualitative case study. Blood Coagul Fibrinolysis. 2009;20(2):146-149. Akassoglou K, Adams RA, Bauer J, et al. Fibrin depletion decreases inflammation and delays the onset of demyelination in a tumor necrosis factor transgenic mouse model for multiple sclerosis. Proc Natl Acad Sci USA. 2004;101(17):6698-6703. Bardos H, Molnar P, Csecsei G, Adany R. Fibrin deposition in primary and metastatic human brain tumours. Blood Coagul Fibrinolysis. 1996;7:536-548.

Neprinol is a revolutionary blend of systemic enzymes and antioxidants specially formulated to support healthy circulatory and immune function.* Neprinol's vegetarian enzyme blend tested to be more than 500% more fibrinolytic than the leading animal-based enzyme formulation.† Neprinol's blend of systemic enzymes are similar to digestive enzymes, but are primarily used throughout the bloodstream rather than the gastrointestinal tract. Neprinol supports healthy levels of Endogenous Blood Particles or EBP’s.* EBP’s can be decayed cells, fibrin, fatty proteins, and other unwanted materials that normally accumulate in the blood.* Systemic enzymes like those in Neprinol support the body’s natural purification of these EBP’s, as well as maintaining healthy liver function and healthy inflammatory levels. Sustaining a healthy level of EBP’s is also beneficial for maintaining optimal immune and circulatory function.* Efficacy is of utmost importance to doctors and patients alike and Neprinol addresses this concern with a proven potency that can be utilized by healthcare professionals. Neprinol’s enzymes are remarkably different from typical animal derived systemic enzymes, which are sometimes derived from pork and cow sources. The enzymes in Neprinol are a combination of vegetarian and selectively potent microbial strains. Although these ingredients are extremely potent, they are well tolerated in the body. Neprinol can be recommended for both clinical use and therapeutic applications. Recent medical breakthroughs, including clinical research performed on Neprinol, have led to the application of systemic enzymes to support the digestion of debris from the cardiovascular system.* This provides for a reduced level of EBP’s, which can support healthy inflammatory responses and their relation to joint discomfort and stiffness.* Healthy, reduced-EBP blood sustains relatively normal blood clotting factors as well. Enzymes support a healthy immune system and may support the repair damaged tissues, and even more remarkably, they require smaller doses over time to maintain their efficacy.* Systemic enzyme products have been and continue to be under-utilized dietary aids, despite the fact that their use dates back further than most supplements. As we age, the need for enzymes increases significantly. Enzymes are essential to maintain a strong immune system, healthy joints, good circulation and overall balanced reaction to injury.* All of the enzyme components in Neprinol are derived from all-vegetarian sources, which by nature are biochemically more effective than those produced by the human body.* Supplementing with Neprinol, can replace these lost and valuable enzymes. Combined with proper diet and exercise they may drastically reduce vulnerability to a wide range of health concerns.* †Based on 3rd party fibrinolytic assay testing. Fibrin Defense Fibrin is a protein formed in the human body responsible for scar tissue and thrombus formation. Neprinol contains a blend of fibrinolytic (fibrin degrading) enzymes that specifically address fibrin levels in the body. Our bodies normally secrete sufficient levels of plasmin, an important enzyme present in the blood that degrades many blood plasma proteins and blood clots. Plasmin, our own natural blood thinner, is responsible for maintaining normal blood solvency by removing unnecessary accumulated protein. The normal process of removing excessive fibrin can be enhanced by introducing fibrinolytic enzymes like those found in Neprinol. Fibrinogen Over-Production Hyper-coagulation & Fibrin Defense Enzymes can be thought of as proteins on a mission. And when it comes to improving your health, one of the most potent targets an enzyme can seek and destroy is a fibrous protein called fibrin. Neprinol contains a powerful combination of fibrin-dissolving enzymes like serrapeptase, nattokinase and bromelain, as well as other natural ingredients. That is why it is known as Neprinol AFD – Advanced Fibrin Defense®. But to understand why the body needs help defending itself against fibrin you first need to understand a bit more about the protein itself. Fibrin Fibrin is an insoluble protein that plays a major role in the formation of blood clots and scar tissue. During the blood clotting process, the soluble protein fibrinogen converts into insoluble fibrin, which is then laid down inside the damaged blood vessel. The fibrin strands then assemble into a net-like gel that hardens and captures all of the materials necessary to patch the damaged vessel. This is the structural framework of a blood clot. Obviously, fibrin plays a vital role in the healing process; however, when there is fibrin overproduction, it can lead to the formation of dangerous and unnecessary blood clots in the body [1]. One factor that can lead to excessive fibrin is ageing. As we age, the concentration of fibrinogen increases in our blood [2]. High levels of fibrinogen increases fibrin production, and as fibrin begins to accumulate in the blood vessels it generally leads to the formation of blood clots [3]. Healthy individuals usually have sufficient levels of plasmin, an enzyme that breaks up fibrin blood clots. Unfortunately plasmin production slows down as we get older so the normal process of removing excess fibrin is reduced. The result of this can be cardiovascular disease, heart attacks, strokes, pulmonary emboli, deep vein thrombosis (DVT) and other related disorders [4-8]. Neprinol Research has shown that protein-dissolving enzymes like those found in Neprinol can slow the production of fibrin and enhance its removal from the body [1]. Neprinol's blend of enzymes generally tests well above 50,000 FU per gram, which means that 50,000 units of fibrin are broken down by each gram of Neprinol powder. Of the enzymes contained in this formula perhaps the most significant is nattokinase, which has been shown to be four times more powerful than our body's own plasmin at breaking down blood clots [9]. Nattokinase Nattokinase is an enzyme extracted from natto, a fermented soybean 'cheese' that is popular in Japan [10]. The ability of nattokinase to breakdown fibrin has been tested in more than 12 studies [11], and nattokinase has been shown to be the most potent fibrin-degrading enzyme out of more than 200 foods tested [3]. Researchers have found that nattokinase works much in the same way as plasmin [3], which means thatnattokinase literally dissolves fibrin, whether it is holding together blood clots or is part of scar tissue [12]. However, nattokinase also blocks the activity of plasminogen activator inhibitor 1 (PAI-1), which boosts its fibrin-destroying capabilities even more [9,13]. Plasminogen is made into plasmin, the body's fibrin-dissolving enzyme. However, the conversion process is inactivated by PAI-1. This is why high levels of PAI-1 reduce fibrin breakdown and removal [14]. Nattokinase increases fibrin breakdown by blocking PAI-1 so that more plasmin is produced. Because of this nattokinase is not only able to stop dangerous blood clots from developing but also helps dissolve any clots that have already formed. As a result, oral nattokinase supplements are recommended for preventing cardiovascular disease [15]. Nattokinase has also been shown to reduce the risk of deep vein thrombosis (DVT) in high-risk patients in combination with pycnogenol[16]. Bromelain Bromelain is an extract from pineapple that contains a number of fibrin-degrading enzymes [17,18], as well as enzymes that enhance this fibrin-dissolving action [19]. Bromelain was shown to increase the conversion of plasminogen into plasmin [20-22]. It has also been shown to prevent the conversion of fibrinogen to fibrin [17]. However, unlike nattokinase, bromelain is not able to dissolve fibrin clumps that have already formed [17]. Because a high percentage of ingested bromelain is absorbed intact into the bloodstream, protein- and fibrin-degrading activity in the blood can be increased for hours after taking it [23]. Two large-scale trials in patients with heart problems showed that bromelain could almost completely eliminate thrombosis [24]. Serrapeptase Serrapeptase is another important component of Neprinol's advanced fibrin defense. Serrapeptase is a protein-degrading enzyme isolated from the silk worm [25]. It has significant anti-inflammatory and fibrin-removal activity [26], which makes it ideal for preventing blood clot formation associated with cardiovascular disease. Other Diseases Linked to Fibrin The buildup of excess fibrin in the body can cause more health problems than just blood clots. Fibrin has also been linked to a number of chronic and progressive diseases like multiple sclerosis [27,28] and asthma [29]. As a result, Neprinol's fibrin-degrading enzymes could prove to be a good treatment option [1,30]. Breaking down fibrin using enzymes may also help a number of conditions that are difficult to treat, such as Peyronie’s disease, Dupuytren’s contracture and Ledderhose’s disease. All of these conditions are characterized by a loss of tissue elasticity, which leads to tissue tearing, then bleeding, clot formation and fibrin deposition. Over time, taking fibrin-degrading enzymes may reduce the amount of scar tissue built up in locations where there has been repeated damage and bleeding [1]. Finally, using enzymes to dissolve fibrin may also play a role in cancer prevention and treatment. Cancer cells often are surrounded by a fibrin coating [31]. Researchers think that the fibrin may provide a type of camouflage for these abnormal cells, allowing them to escape being destroyed by the immune system. It is possible that by removing this fibrin coating, the body could detect cancer cells and destroy them before they are able to gain a foothold in the body. Advanced Fibrin Defense As you can see, excess fibrin can wreak havoc on our bodies, especially as we get older and our natural production of enzymes decreases. However, Neprinol provides a combination of superior fibrin-active enzymes designed to keep fibrin levels in check. Neprinol is an excellent choice for anyone suffering from, or hoping to prevent, the harmful effects of excess fibrin. Suggested Use Directions: Take 1 to 4 capsules with 8 oz of water between meals or as directed by your healthcare practitioner. For therapeutic results, take 3 or 4 capsules three times daily. Warning: Do not take Neprinol without the consent of your physician if you are taking anti-coagulants or if you are pregnant or nursing. Is Neprinol safe? No serious or adverse side effects have been reported from taking systemic enzymes such as Neprinol. Clinical studies have shown that even extremely large doses of these enzymes are not toxic. If you are taking blood-thinning medication, you should consult with your physician before taking Neprinol. When is the best time to take Neprinol? For best results, take the product atleast one hour prior to eating and/or two hours after a meal. Can I take Neprinol with other supplements? Neprinol can be used safely with other dietary supplements. How long does it take for Neprinol to work? Although every person is different, some have reported feeling the effects of systemic enzymes in as little as 45 minutes. For therapeutic regimens, the progression may be slow for some and quicker for others. Typically, supplementing the product for a minimum of a month's time is recommended, with the best results occurring anywhere from one to three months thereafter. Supplement Facts Nattokinase A fibrinolytic enzyme derived from the fermentation of Bacillus subtilis that can help to maintain normal blood viscosity and normal cardiovascular health.SerrapeptaseA proteolytic (protein digesting) enzyme with potent fibrinolytic activity can support healthy fibrin concentrations. It has been clinically shown to support healthy mucus viscosity and promote normal recovery after physical stress.LipaseUsed systemically, this enzyme digests fats in the blood and can help convert fats into fatty acids, which may be expressed or retained as energy.ProteaseA proteolytic enzyme that, when present in blood serum, plays an important role in the blood’s health. It can also help support a healthy immune system and improve circulatory health.AmlaDerived from Indian Gooseberry, amla contains tannic acid, glucose, cellulose, and calcium. Amla helps maintain pH balance, and has a high concentration of naturally derived vitamin C.PapainA proteolytic enzyme derived from papaya that can promote normal healing and inflammation from overexertion.RutinA flavonoid (plant pigment) that helps to maintain strong capillaries and connective tissue, as well as healthy blood vessels.CoQ10Decreases the proliferation of free radicals, supporting a healthy immune system. CoQ10 helps promote maintenance of normal cardiovascular function and is a coenzyme that is essential for enzymes to function in the body.MagnesiumPromotes a healthy cardiovascular system, and is essential for cell repair, hormones, and a regular heartbeat. Magnesium also helps reduce the effects of increased stress. Other Ingredients: Cellulose (Acid Amor™ capsules) Neprinol™ is free of dairy, gluten, and soy allergens. Contains no artificial colors or preservatives. Keep out of reach of children. Store in a cool, dry place with lid tightly closed. WARNING: Do not take this product without the consent of your physician if you are currently taking anti-coagulants or if you are pregnant or nursing. Frequently Asked Questions What is Neprinol? Neprinol is a proprietary combination of Serrapeptase, Nattokinase, Protease, Lipase, Bromelain, Papain, Rutin, Amla and other proteolytic enzymes that are specially formulated to assist your body's defense of the damaging effects of fibrin. Neprinol has been used to strengthen the immune and circulatory systems, maintain a healthy inflammatory response and to support the body's natural recovery process.* What are Enzymes? Enzymes are proteins (or protein-based molecules) that act as catalysts in biochemical reactions. Every enzyme has a specific reactant known as a substrate, which can be thought of like a lock and a key. Only a specific enzyme (or key) will react (or unlock) its substrate. This is the reason why enzymes are unable to break down necessary and vital tissue, as they only react with certain harmful proteins in the body. What are "Systemic Enzymes"? When enzymes are introduced into the bloodstream, they work “systemically”, or throughout the entire body. Taking enzymes on an empty stomach allows them to work systemically since they will bypass the upper digestive process and enter the bloodstream through the intestine. Systemic enzymes are similar to digestive enzymes, though certain enzymes are better designed for systemic activity as opposed to digestion due to the materials they react with, such as Serrapeptase and Nattokinase. These two enzymes are very efficient with the breakdown of a particular substance known as Fibrin. What is Fibrin? Fibrin is a protein substance naturally formed in the human body that plays a significant role in our health and general well-being. Fibrin is responsible for scar tissue formation, and is produced as a reaction to injury. Our bodies naturally maintain healthy fibrin levels with enzymes (principally plasmin) whose role is to attack and break down any excessive fibrin. As fibrin builds up in the body, it can cause many unhealthy conditions. Why Neprinol? As we age, our natural enzyme production decreases while the need for these enzymes is of increasing importance. Supplementing these valuable enzymes can combat enzyme deficiencies that can lead to a wide variety of health concerns. Healthy levels of these enzymes can assist the body in maintaining a healthy immune system, healthy joints, proper circulation and an overall balanced reaction to injury. How Does Neprinol Work? By supplementing and replenishing the body's diminishing enzymes, Neprinol provides one of our most essential and basic biochemical needs. It supplements the body's natural fibrinolytic enzyme levels thereby helping to maintain healthy fibrin levels: an underlying causative agent for many unhealthy conditions in the body.* Is Neprinol Enteric Coated? Enteric coatings are designed to protect enzymes and other supplements from stomach acid. Plastic-like chemicals known as phthalates are often used in this coating process. Phthalates are actually banned in children's toys in Europe and Mexico, so why would we ever include these in our formulas? Arthur Andrew Medical has instead developed an all-natural, chemical-free Acid Armor capsule. These capsules are comprised of an extra-thick layer of cellulose (vegetable capsules) with a micro threaded locking mechanism to prevent leaking. Acid Armor capsules have been designed to delay the release of the capsule's contents for up to an hour without the use of potentially harmful chemicals. Is Neprinol Safe? No serious or adverse side effects have been reported from taking systemic enzymes such as Neprinol*. Clinical studies have shown that even extremely large doses of these enzymes are not toxic. If you are taking blood-thinning medication, you should consult with your physician before taking Neprinol. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Neprinol contains Pharmaceutical-grade ingredients. The product is provided exclusively through licensed health-care practitioners and supplementation outlet stores. Neprinol is 100% natural and contains no animal derivatives. References: Meletis CD, Barker JE. Therapeutic enzymes: using the body's helpers as healers. Alt Comp Ther. 2005;74-77. Meade TW. Fibrinogen and cardiovascular disease. J Clin Pathol. 1997;50:13-15. Milner M, Makise K. Natto and its Active Ingredient Nattokinase: a potent and safe thrombolytic agent. Alt Comp Therap. 2002;8(3):157-164. Koenig W. Fibrin(ogen) in cardiovascular disease: an update. Thromb Haemost. 2003;89:601-609. Lefevre M, Kris-Etherton PM, Zhao G, Tracy RP. Dietary fatty acids, hemostasis, and cardiovascular disease risk. J Am Diet Assoc. 2004;104:410-419. Kannel WB. Overview of hemostatic factors involved in atherosclerotic cardiovascular disease.Lipids. 2005;40:1215-1220. Eidelman RS, Hennekens CH. Fibrinogen: a predictor of stroke and marker of atherosclerosis.Eur Heart J. 2003;24:499-500. Nesheim M. Myocardial infarction and the balance between fibrin deposition and removal. Ital Heart J. 2001;2:641-645. Fujita M, Hong K, Ito Y, et al. Thrombolytic effect of nattokinase on a chemically induced thrombosis model in rat. Biol Pharm Bull. 1995;18:1387-1391. Sumi H, Hamada H, Tsushima H, Mihara H, Muraki H. A novel fibrinolytic enzyme (nattokinase) in the vegetable cheese Natto; a typical and popular soybean food in the Japanese diet.Experientia. 1987;43:1110-1111. Pais E, Alexy T, Holsworth RE Jr, Meise HJ. Effects of nattokinase, a pro-fibrinolytic enzyme, on red blood cell aggregation and whole blood viscosity. Clin Hemorheol Microcirc. 2006;35:139-142. Sumi H, Hamada H, Nakanishi K, Hiratani H. Enhancement of the fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol. 1990;84:139-143. Suzuki Y, Kondo K, Matsumoto Y, et al. Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci. 2003;73:1289-1298. Hamsten A, de Faire U, Walldius G, et al. Plasminogen activator inhibitor in plasma: risk factor for recurrent myocardial infarction.Lancet. 1987;2:3-9. Hsia C-H, Shen M-C, Lin J-S, et al. Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects. Nutr Res. 2009;29:190-196. Cesarone MR, Belcaro G, Nicolaides AN, et al. Prevention of venous thrombosis in long-haul flights with Flite Tabs: The LONFLIT-FLITE randomized, controlled trial. Angiology. 2003;54:531-539. Maurer HR. Bromelain: biochemistry, pharmacology and medical use. Cell Mol Life Sci.2001;58:1234-1245. Pirotta F, de Giuli-Morghen C. Bromelain: antiinflammatory and serum fibrinolytic activity after oral administration in the rat. Drugs Exp Clin Res. 1978;4:1-20. Ako H, Cheung AH, Matsuura PK. Isolation of a fibrinolysis enzyme activator from commercial bromelain. Arch Int Pharmacodyn Ther. 1981;254(1):157-167. Maurer HR, Eckert K, Grabowska E, Eschmann K. Use of bromelain proteases for inhibiting blood coagulation. Patent WO PCT/EP 98/04406. 2000. De-Giuli M, Pirotta F. Bromelain, interaction with some protease inhibitor and rabbit specific antiserum. Drugs Exp Clin Res. 1978;4:21-23. Smyth RD, Brennan R, Martin GJ. Systemic biochemical changes following the oral administration of a proteolytic enzyme, bromelain. Arch Int Pharmacodyn. 1962;136:230-236. Taussig SJ. The mechanism of the physiological action of bromelain. Med Hypotheses. 1980;6(1):99-104. Felton GE. Fibrinolytic and antithrombotic action of bromelain may eliminate thrombosis in heart patients. Med Hypotheses. 1980;6(1):1123-1133. Sandhya KV, Devi SG, Mathew ST. Quantitation of serrapeptase in formulations by UV method in the microplate format. Curr Drug Deliv. 2008;5(4):303-305. Mazzone A, Catalani M, Costanzo M, et al. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: A multicentre, doubleblind, randomized trial versus placebo. J Int Med Res. 1990;18:379-388. Sobel RA, Mitchell ME. Fibronectin in multiple sclerosis lesions. Am J Pathol.1989;135:161-168. Gveric D, Hanemaaijer R, Newcombe J, van Lent NA, Sier CF, Cuzner ML. Plasminogen activators in multiple sclerosis lesions: implications for the inflammatory response and axonal damage. Brain.2001;124(Pt 10):1978-1988. Pretorius E, Oberholzer HM. Ultrastructural changes of platelets and fibrin networks in human asthma: a qualitative case study. Blood Coagul Fibrinolysis. 2009;20(2):146-149. Akassoglou K, Adams RA, Bauer J, et al. Fibrin depletion decreases inflammation and delays the onset of demyelination in a tumor necrosis factor transgenic mouse model for multiple sclerosis. Proc Natl Acad Sci USA. 2004;101(17):6698-6703. Bardos H, Molnar P, Csecsei G, Adany R. Fibrin deposition in primary and metastatic human brain tumours. Blood Coagul Fibrinolysis. 1996;7:536-548.

Triple Magnesium Power for Everyday Wellness ✔️ 3 Forms of Highly Bioavailable Magnesium✔️ Nutrient Support for Mood & Stress Balance✔️ Mineral Support for Bone, Joint & Muscle Function Mag3Ultra® combines three advanced, bioavailable forms of magnesium—Sucrosomial Magnesium Oxide, Magnesium Taurate, and Magnesium Bisglycinate—with Potassium Gluconate and Ascorbyl Palmitate (fat-soluble Vitamin C) to support a variety of important physiological processes. Designed to complement your daily routine, Mag3Ultra® offers a comprehensive mineral profile in a thoughtfully formulated blend. How It Works Many magnesium supplements are associated with gastrointestinal discomfort due to low absorption. Mag3Ultra® features Sucrosomial Magnesium, a delivery system that encapsulates magnesium in a sucrosome matrix—helping it pass through the stomach more comfortably and reach the intestines for better uptake. Functional Benefits Well-Tolerated Magnesium The sucrosomial delivery system helps magnesium travel through the digestive tract more gently compared to some conventional forms. Structural Support Magnesium is involved in numerous cellular functions related to the body’s framework and structure. The combination of minerals in Mag3Ultra® is designed to complement these physiological roles. Muscle Function Magnesium and potassium contribute to normal muscle activity. This formula is developed with ingredients known to play a role in muscle-related pathways. Everyday Balance Magnesium participates in enzyme activity and cellular signalling processes. Mag3Ultra® provides forms of magnesium that are bioavailable and well-tolerated to support daily nutritional needs. Ingredients Sucrosomial Magnesium OxideA form of magnesium encapsulated in a lipid matrix to support absorption and digestive comfort. Magnesium TaurateCombines magnesium with taurine, an amino acid-like compound. Magnesium BisglycinateA chelated form of magnesium, known for its solubility and mild profile. Potassium GluconateA source of potassium that contributes to fluid balance and normal muscle function. Ascorbyl PalmitateA fat-soluble form of Vitamin C, often used for its antioxidant properties and stability in formulations. Suggested Use General Use: Take 1–3 capsules per day, or as directed by a healthcare practitioner. Higher Intake: Take 4–6 capsules per day, in divided doses, or as directed by a healthcare practitioner. Always consult your healthcare provider for guidance. This product is not intended to diagnose, treat, cure, or prevent any disease. If you are pregnant, breastfeeding, taking medication, or have a medical condition, consult your healthcare professional before use. Keep out of reach of children. Do not exceed the recommended daily dose. FAQs Is Sucrosomial Magnesium different from regular magnesium oxide?Yes, Sucrosomial Magnesium differs significantly from regular magnesium oxide. While magnesium oxide is commonly found in supplements due to its high elemental magnesium content (around 61%), Sucrosomial Magnesium utilizes magnesium oxide encapsulated within a sucrosome for improved digestive tolerability and absorption. Despite containing a lower percentage of elemental magnesium (around 31%), Sucrosomial Magnesium has been shown to be more bioavailable than magnesium oxide alone. High elemental magnesium content in magnesium oxide can be harsh on the digestive tract, making the Sucrosomial form a preferable option. Is Mag3Ultra missing calcium?Dietary calcium deficiency is a major problem globally. However, it is not a lack of calcium that creates this deficiency, proper calcium absorption and utilization is the problem. Mag3Ultra supports proper magnesium levels so that calcium is utilized properly. For the most optimal use of calcium, we recommend taking Mag3Ultra with Vitamin D3, and Vitamin K2. The latter two vitamins can be found in KD Ultra, our premier blend of vegan Vitamin D3 and Vitamin K2. When is the best time to take Mag3Ultra?The best time to take Mag3Ultra is with meals to minimize the risk of digestive issues and maximize absorption. If you don't experience the desired benefits with meals, you can try taking it between meals or before bed after ensuring your body tolerates magnesium well. Mag3Ultra contains three highly tolerated forms of magnesium, but starting with meals is advisable to assess your body's response to the product. Is Mag3Ultra Kosher?The product is certified Kosher by Star-K, and a copy of the certification is available upon request. Is Mag3Ultra vegan friendly?The formula is vegan in accordance with the guidelines of the American Vegetarian Association. Note: This product is not intended to diagnose, treat, cure, or prevent any disease. If you are pregnant, breastfeeding, taking medication, or have a medical condition, consult your healthcare professional before use. Keep out of reach of children. Do not exceed the recommended daily dose.

Neprinol is a revolutionary blend of systemic enzymes and antioxidants specially formulated to support healthy circulatory and immune function.* Neprinol's vegetarian enzyme blend tested to be more than 500% more fibrinolytic than the leading animal-based enzyme formulation.† Neprinol's blend of systemic enzymes are similar to digestive enzymes, but are primarily used throughout the bloodstream rather than the gastrointestinal tract. Neprinol supports healthy levels of Endogenous Blood Particles or EBP’s.* EBP’s can be decayed cells, fibrin, fatty proteins, and other unwanted materials that normally accumulate in the blood.* Systemic enzymes like those in Neprinol support the body’s natural purification of these EBP’s, as well as maintaining healthy liver function and healthy inflammatory levels. Sustaining a healthy level of EBP’s is also beneficial for maintaining optimal immune and circulatory function.* Efficacy is of utmost importance to doctors and patients alike and Neprinol addresses this concern with a proven potency that can be utilized by healthcare professionals. Neprinol’s enzymes are remarkably different from typical animal derived systemic enzymes, which are sometimes derived from pork and cow sources. The enzymes in Neprinol are a combination of vegetarian and selectively potent microbial strains. Although these ingredients are extremely potent, they are well tolerated in the body. Neprinol can be recommended for both clinical use and therapeutic applications. Recent medical breakthroughs, including clinical research performed on Neprinol, have led to the application of systemic enzymes to support the digestion of debris from the cardiovascular system.* This provides for a reduced level of EBP’s, which can support healthy inflammatory responses and their relation to joint discomfort and stiffness.* Healthy, reduced-EBP blood sustains relatively normal blood clotting factors as well. Enzymes support a healthy immune system and may support the repair damaged tissues, and even more remarkably, they require smaller doses over time to maintain their efficacy.* Systemic enzyme products have been and continue to be under-utilized dietary aids, despite the fact that their use dates back further than most supplements. As we age, the need for enzymes increases significantly. Enzymes are essential to maintain a strong immune system, healthy joints, good circulation and overall balanced reaction to injury.* All of the enzyme components in Neprinol are derived from all-vegetarian sources, which by nature are biochemically more effective than those produced by the human body.* Supplementing with Neprinol, can replace these lost and valuable enzymes. Combined with proper diet and exercise they may drastically reduce vulnerability to a wide range of health concerns.* †Based on 3rd party fibrinolytic assay testing. Fibrin Defense Fibrin is a protein formed in the human body responsible for scar tissue and thrombus formation. Neprinol contains a blend of fibrinolytic (fibrin degrading) enzymes that specifically address fibrin levels in the body. Our bodies normally secrete sufficient levels of plasmin, an important enzyme present in the blood that degrades many blood plasma proteins and blood clots. Plasmin, our own natural blood thinner, is responsible for maintaining normal blood solvency by removing unnecessary accumulated protein. The normal process of removing excessive fibrin can be enhanced by introducing fibrinolytic enzymes like those found in Neprinol. Fibrinogen Over-Production Hyper-coagulation & Fibrin Defense Enzymes can be thought of as proteins on a mission. And when it comes to improving your health, one of the most potent targets an enzyme can seek and destroy is a fibrous protein called fibrin. Neprinol contains a powerful combination of fibrin-dissolving enzymes like serrapeptase, nattokinase and bromelain, as well as other natural ingredients. That is why it is known as Neprinol AFD – Advanced Fibrin Defense®. But to understand why the body needs help defending itself against fibrin you first need to understand a bit more about the protein itself. Fibrin Fibrin is an insoluble protein that plays a major role in the formation of blood clots and scar tissue. During the blood clotting process, the soluble protein fibrinogen converts into insoluble fibrin, which is then laid down inside the damaged blood vessel. The fibrin strands then assemble into a net-like gel that hardens and captures all of the materials necessary to patch the damaged vessel. This is the structural framework of a blood clot. Obviously, fibrin plays a vital role in the healing process; however, when there is fibrin overproduction, it can lead to the formation of dangerous and unnecessary blood clots in the body [1]. One factor that can lead to excessive fibrin is ageing. As we age, the concentration of fibrinogen increases in our blood [2]. High levels of fibrinogen increases fibrin production, and as fibrin begins to accumulate in the blood vessels it generally leads to the formation of blood clots [3]. Healthy individuals usually have sufficient levels of plasmin, an enzyme that breaks up fibrin blood clots. Unfortunately plasmin production slows down as we get older so the normal process of removing excess fibrin is reduced. The result of this can be cardiovascular disease, heart attacks, strokes, pulmonary emboli, deep vein thrombosis (DVT) and other related disorders [4-8]. Neprinol Research has shown that protein-dissolving enzymes like those found in Neprinol can slow the production of fibrin and enhance its removal from the body [1]. Neprinol's blend of enzymes generally tests well above 50,000 FU per gram, which means that 50,000 units of fibrin are broken down by each gram of Neprinol powder. Of the enzymes contained in this formula perhaps the most significant is nattokinase, which has been shown to be four times more powerful than our body's own plasmin at breaking down blood clots [9]. Nattokinase Nattokinase is an enzyme extracted from natto, a fermented soybean 'cheese' that is popular in Japan [10]. The ability of nattokinase to breakdown fibrin has been tested in more than 12 studies [11], and nattokinase has been shown to be the most potent fibrin-degrading enzyme out of more than 200 foods tested [3]. Researchers have found that nattokinase works much in the same way as plasmin [3], which means thatnattokinase literally dissolves fibrin, whether it is holding together blood clots or is part of scar tissue [12]. However, nattokinase also blocks the activity of plasminogen activator inhibitor 1 (PAI-1), which boosts its fibrin-destroying capabilities even more [9,13]. Plasminogen is made into plasmin, the body's fibrin-dissolving enzyme. However, the conversion process is inactivated by PAI-1. This is why high levels of PAI-1 reduce fibrin breakdown and removal [14]. Nattokinase increases fibrin breakdown by blocking PAI-1 so that more plasmin is produced. Because of this nattokinase is not only able to stop dangerous blood clots from developing but also helps dissolve any clots that have already formed. As a result, oral nattokinase supplements are recommended for preventing cardiovascular disease [15]. Nattokinase has also been shown to reduce the risk of deep vein thrombosis (DVT) in high-risk patients in combination with pycnogenol[16]. Bromelain Bromelain is an extract from pineapple that contains a number of fibrin-degrading enzymes [17,18], as well as enzymes that enhance this fibrin-dissolving action [19]. Bromelain was shown to increase the conversion of plasminogen into plasmin [20-22]. It has also been shown to prevent the conversion of fibrinogen to fibrin [17]. However, unlike nattokinase, bromelain is not able to dissolve fibrin clumps that have already formed [17]. Because a high percentage of ingested bromelain is absorbed intact into the bloodstream, protein- and fibrin-degrading activity in the blood can be increased for hours after taking it [23]. Two large-scale trials in patients with heart problems showed that bromelain could almost completely eliminate thrombosis [24]. Serrapeptase Serrapeptase is another important component of Neprinol's advanced fibrin defense. Serrapeptase is a protein-degrading enzyme isolated from the silk worm [25]. It has significant anti-inflammatory and fibrin-removal activity [26], which makes it ideal for preventing blood clot formation associated with cardiovascular disease. Other Diseases Linked to Fibrin The buildup of excess fibrin in the body can cause more health problems than just blood clots. Fibrin has also been linked to a number of chronic and progressive diseases like multiple sclerosis [27,28] and asthma [29]. As a result, Neprinol's fibrin-degrading enzymes could prove to be a good treatment option [1,30]. Breaking down fibrin using enzymes may also help a number of conditions that are difficult to treat, such as Peyronie’s disease, Dupuytren’s contracture and Ledderhose’s disease. All of these conditions are characterized by a loss of tissue elasticity, which leads to tissue tearing, then bleeding, clot formation and fibrin deposition. Over time, taking fibrin-degrading enzymes may reduce the amount of scar tissue built up in locations where there has been repeated damage and bleeding [1]. Finally, using enzymes to dissolve fibrin may also play a role in cancer prevention and treatment. Cancer cells often are surrounded by a fibrin coating [31]. Researchers think that the fibrin may provide a type of camouflage for these abnormal cells, allowing them to escape being destroyed by the immune system. It is possible that by removing this fibrin coating, the body could detect cancer cells and destroy them before they are able to gain a foothold in the body. Advanced Fibrin Defense As you can see, excess fibrin can wreak havoc on our bodies, especially as we get older and our natural production of enzymes decreases. However, Neprinol provides a combination of superior fibrin-active enzymes designed to keep fibrin levels in check. Neprinol is an excellent choice for anyone suffering from, or hoping to prevent, the harmful effects of excess fibrin. Suggested Use Directions: Take 1 to 4 capsules with 8 oz of water between meals or as directed by your healthcare practitioner. For therapeutic results, take 3 or 4 capsules three times daily. Warning: Do not take Neprinol without the consent of your physician if you are taking anti-coagulants or if you are pregnant or nursing. Is Neprinol safe? No serious or adverse side effects have been reported from taking systemic enzymes such as Neprinol. Clinical studies have shown that even extremely large doses of these enzymes are not toxic. If you are taking blood-thinning medication, you should consult with your physician before taking Neprinol. When is the best time to take Neprinol? For best results, take the product atleast one hour prior to eating and/or two hours after a meal. Can I take Neprinol with other supplements? Neprinol can be used safely with other dietary supplements. How long does it take for Neprinol to work? Although every person is different, some have reported feeling the effects of systemic enzymes in as little as 45 minutes. For therapeutic regimens, the progression may be slow for some and quicker for others. Typically, supplementing the product for a minimum of a month's time is recommended, with the best results occurring anywhere from one to three months thereafter. Supplement Facts Nattokinase A fibrinolytic enzyme derived from the fermentation of Bacillus subtilis that can help to maintain normal blood viscosity and normal cardiovascular health.SerrapeptaseA proteolytic (protein digesting) enzyme with potent fibrinolytic activity can support healthy fibrin concentrations. It has been clinically shown to support healthy mucus viscosity and promote normal recovery after physical stress.LipaseUsed systemically, this enzyme digests fats in the blood and can help convert fats into fatty acids, which may be expressed or retained as energy.ProteaseA proteolytic enzyme that, when present in blood serum, plays an important role in the blood’s health. It can also help support a healthy immune system and improve circulatory health.AmlaDerived from Indian Gooseberry, amla contains tannic acid, glucose, cellulose, and calcium. Amla helps maintain pH balance, and has a high concentration of naturally derived vitamin C.PapainA proteolytic enzyme derived from papaya that can promote normal healing and inflammation from overexertion.RutinA flavonoid (plant pigment) that helps to maintain strong capillaries and connective tissue, as well as healthy blood vessels.CoQ10Decreases the proliferation of free radicals, supporting a healthy immune system. CoQ10 helps promote maintenance of normal cardiovascular function and is a coenzyme that is essential for enzymes to function in the body.MagnesiumPromotes a healthy cardiovascular system, and is essential for cell repair, hormones, and a regular heartbeat. Magnesium also helps reduce the effects of increased stress. Other Ingredients: Cellulose (Acid Amor™ capsules) Neprinol™ is free of dairy, gluten, and soy allergens. Contains no artificial colors or preservatives. Keep out of reach of children. Store in a cool, dry place with lid tightly closed. WARNING: Do not take this product without the consent of your physician if you are currently taking anti-coagulants or if you are pregnant or nursing. Frequently Asked Questions What is Neprinol? Neprinol is a proprietary combination of Serrapeptase, Nattokinase, Protease, Lipase, Bromelain, Papain, Rutin, Amla and other proteolytic enzymes that are specially formulated to assist your body's defense of the damaging effects of fibrin. Neprinol has been used to strengthen the immune and circulatory systems, maintain a healthy inflammatory response and to support the body's natural recovery process.* What are Enzymes? Enzymes are proteins (or protein-based molecules) that act as catalysts in biochemical reactions. Every enzyme has a specific reactant known as a substrate, which can be thought of like a lock and a key. Only a specific enzyme (or key) will react (or unlock) its substrate. This is the reason why enzymes are unable to break down necessary and vital tissue, as they only react with certain harmful proteins in the body. What are "Systemic Enzymes"? When enzymes are introduced into the bloodstream, they work “systemically”, or throughout the entire body. Taking enzymes on an empty stomach allows them to work systemically since they will bypass the upper digestive process and enter the bloodstream through the intestine. Systemic enzymes are similar to digestive enzymes, though certain enzymes are better designed for systemic activity as opposed to digestion due to the materials they react with, such as Serrapeptase and Nattokinase. These two enzymes are very efficient with the breakdown of a particular substance known as Fibrin. What is Fibrin? Fibrin is a protein substance naturally formed in the human body that plays a significant role in our health and general well-being. Fibrin is responsible for scar tissue formation, and is produced as a reaction to injury. Our bodies naturally maintain healthy fibrin levels with enzymes (principally plasmin) whose role is to attack and break down any excessive fibrin. As fibrin builds up in the body, it can cause many unhealthy conditions. Why Neprinol? As we age, our natural enzyme production decreases while the need for these enzymes is of increasing importance. Supplementing these valuable enzymes can combat enzyme deficiencies that can lead to a wide variety of health concerns. Healthy levels of these enzymes can assist the body in maintaining a healthy immune system, healthy joints, proper circulation and an overall balanced reaction to injury. How Does Neprinol Work? By supplementing and replenishing the body's diminishing enzymes, Neprinol provides one of our most essential and basic biochemical needs. It supplements the body's natural fibrinolytic enzyme levels thereby helping to maintain healthy fibrin levels: an underlying causative agent for many unhealthy conditions in the body.* Is Neprinol Enteric Coated? Enteric coatings are designed to protect enzymes and other supplements from stomach acid. Plastic-like chemicals known as phthalates are often used in this coating process. Phthalates are actually banned in children's toys in Europe and Mexico, so why would we ever include these in our formulas? Arthur Andrew Medical has instead developed an all-natural, chemical-free Acid Armor capsule. These capsules are comprised of an extra-thick layer of cellulose (vegetable capsules) with a micro threaded locking mechanism to prevent leaking. Acid Armor capsules have been designed to delay the release of the capsule's contents for up to an hour without the use of potentially harmful chemicals. Is Neprinol Safe? No serious or adverse side effects have been reported from taking systemic enzymes such as Neprinol*. Clinical studies have shown that even extremely large doses of these enzymes are not toxic. If you are taking blood-thinning medication, you should consult with your physician before taking Neprinol. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Neprinol contains Pharmaceutical-grade ingredients. The product is provided exclusively through licensed health-care practitioners and supplementation outlet stores. Neprinol is 100% natural and contains no animal derivatives. References: Meletis CD, Barker JE. Therapeutic enzymes: using the body's helpers as healers. Alt Comp Ther. 2005;74-77. Meade TW. Fibrinogen and cardiovascular disease. J Clin Pathol. 1997;50:13-15. Milner M, Makise K. Natto and its Active Ingredient Nattokinase: a potent and safe thrombolytic agent. Alt Comp Therap. 2002;8(3):157-164. Koenig W. Fibrin(ogen) in cardiovascular disease: an update. Thromb Haemost. 2003;89:601-609. Lefevre M, Kris-Etherton PM, Zhao G, Tracy RP. Dietary fatty acids, hemostasis, and cardiovascular disease risk. J Am Diet Assoc. 2004;104:410-419. Kannel WB. Overview of hemostatic factors involved in atherosclerotic cardiovascular disease.Lipids. 2005;40:1215-1220. Eidelman RS, Hennekens CH. Fibrinogen: a predictor of stroke and marker of atherosclerosis.Eur Heart J. 2003;24:499-500. Nesheim M. Myocardial infarction and the balance between fibrin deposition and removal. Ital Heart J. 2001;2:641-645. Fujita M, Hong K, Ito Y, et al. Thrombolytic effect of nattokinase on a chemically induced thrombosis model in rat. Biol Pharm Bull. 1995;18:1387-1391. Sumi H, Hamada H, Tsushima H, Mihara H, Muraki H. A novel fibrinolytic enzyme (nattokinase) in the vegetable cheese Natto; a typical and popular soybean food in the Japanese diet.Experientia. 1987;43:1110-1111. Pais E, Alexy T, Holsworth RE Jr, Meise HJ. Effects of nattokinase, a pro-fibrinolytic enzyme, on red blood cell aggregation and whole blood viscosity. Clin Hemorheol Microcirc. 2006;35:139-142. Sumi H, Hamada H, Nakanishi K, Hiratani H. Enhancement of the fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol. 1990;84:139-143. Suzuki Y, Kondo K, Matsumoto Y, et al. Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci. 2003;73:1289-1298. Hamsten A, de Faire U, Walldius G, et al. Plasminogen activator inhibitor in plasma: risk factor for recurrent myocardial infarction.Lancet. 1987;2:3-9. Hsia C-H, Shen M-C, Lin J-S, et al. Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects. Nutr Res. 2009;29:190-196. Cesarone MR, Belcaro G, Nicolaides AN, et al. Prevention of venous thrombosis in long-haul flights with Flite Tabs: The LONFLIT-FLITE randomized, controlled trial. Angiology. 2003;54:531-539. Maurer HR. Bromelain: biochemistry, pharmacology and medical use. Cell Mol Life Sci.2001;58:1234-1245. Pirotta F, de Giuli-Morghen C. Bromelain: antiinflammatory and serum fibrinolytic activity after oral administration in the rat. Drugs Exp Clin Res. 1978;4:1-20. Ako H, Cheung AH, Matsuura PK. Isolation of a fibrinolysis enzyme activator from commercial bromelain. Arch Int Pharmacodyn Ther. 1981;254(1):157-167. Maurer HR, Eckert K, Grabowska E, Eschmann K. Use of bromelain proteases for inhibiting blood coagulation. Patent WO PCT/EP 98/04406. 2000. De-Giuli M, Pirotta F. Bromelain, interaction with some protease inhibitor and rabbit specific antiserum. Drugs Exp Clin Res. 1978;4:21-23. Smyth RD, Brennan R, Martin GJ. Systemic biochemical changes following the oral administration of a proteolytic enzyme, bromelain. Arch Int Pharmacodyn. 1962;136:230-236. Taussig SJ. The mechanism of the physiological action of bromelain. Med Hypotheses. 1980;6(1):99-104. Felton GE. Fibrinolytic and antithrombotic action of bromelain may eliminate thrombosis in heart patients. Med Hypotheses. 1980;6(1):1123-1133. Sandhya KV, Devi SG, Mathew ST. Quantitation of serrapeptase in formulations by UV method in the microplate format. Curr Drug Deliv. 2008;5(4):303-305. Mazzone A, Catalani M, Costanzo M, et al. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: A multicentre, doubleblind, randomized trial versus placebo. J Int Med Res. 1990;18:379-388. Sobel RA, Mitchell ME. Fibronectin in multiple sclerosis lesions. Am J Pathol.1989;135:161-168. Gveric D, Hanemaaijer R, Newcombe J, van Lent NA, Sier CF, Cuzner ML. Plasminogen activators in multiple sclerosis lesions: implications for the inflammatory response and axonal damage. Brain.2001;124(Pt 10):1978-1988. Pretorius E, Oberholzer HM. Ultrastructural changes of platelets and fibrin networks in human asthma: a qualitative case study. Blood Coagul Fibrinolysis. 2009;20(2):146-149. Akassoglou K, Adams RA, Bauer J, et al. Fibrin depletion decreases inflammation and delays the onset of demyelination in a tumor necrosis factor transgenic mouse model for multiple sclerosis. Proc Natl Acad Sci USA. 2004;101(17):6698-6703. Bardos H, Molnar P, Csecsei G, Adany R. Fibrin deposition in primary and metastatic human brain tumours. Blood Coagul Fibrinolysis. 1996;7:536-548.

Serretia is an incredibly potent pure serrapeptase product. Serretia is rated at 250,000 SPU's per dose. Did you know Serrapeptase is one of the world's finest enzymes that supports normal mucus levels? Serretia is an excellent choice for promoting healthy sinus activity during cold and flu season. Serretia is also the perfect addition to ice to support a normal inflammatory response after sports injuries and invasive procedures. This amazing enzyme is an excellent complement to Neprinol, boosting its ability to reduce occasional discomfort and aiding in normal recovery times.* Originally discovered in the intestine of silkworms, the proteolytic enzyme Serrapeptase is harnessed by Arthur Andrew Medical through the isolation of the microorganism, Serratia E-15. Serrapeptase’s inherent ability to digest dead tissue enables the enzyme to successfully aid in supporting normal scar tissue, normal blood clotting, and allows for more fluid and natural blood flow throughout the body.* Serrétia has a variety of different benefits that may help with the following: Sport injuries* Promote healthy sinus activity* Promote free joint mobility* Muscle tears and pulls* Surgical recovery* Normal fluid retention such as swelling* Potent fibrinolytic activity* Promotes recovery after physical stress* Boosts energy levels* Promotes lean body mass* Suggested Use Directions: Take 2 capsules with 8 oz of water on an empty stomach or as directed by your healthcare practitioner. Maintenance: 2 capsules 1 time per day. Immune Building: 2 capsules 2 times per day. Long Term Immune Support: 2 capsules 3 times per day. Short Term Immune Support: 3 Capsules 3 times per day. Serrétia is an excellent complementary product to any Neprinol or Syntol regimen.* Warning: Do not take Serretia without the consent of your physician if you are taking anti-coagulants or if you are pregnant or nursing.* Is Serrétia safe? No serious or adverse side effects have been reported from taking systemic enzymes such as Serretia.* Supplement Facts Supplement Facts Serving Size: 2 Capsules Amount Per Serving* % Daily Value Serrapeptase 250,000 SPU † * Percent Daily Values based on a 2,000 calorie diet † Daily Value Not Established Other Ingredients: Cellulose (Acid Armor™ Capsules) Serretia™ is free of dairy, gluten, and soy allergens. Contains no artificial colors or preservatives. Keep out of reach of children. Store in a cool, dry place with lid tightly closed. WARNING: Serrapeptase may thin the blood. Consult your physician if you are currently taking anticoagulants Frequently Asked Questions What is Serretia? Serretia is comprised of 99.99% pure Serratiopeptidase, more commonly known as Serrapeptase. Serrapeptase is a proteolytic enzyme originally discovered in the intestine of silkworms, and is produced by Arthur Andrew Medical through the isolation of the microorganism Serratia E-15. In Japan, Serrapeptase is commonly prescribed as a drug, but here in the US we can experience serrapeptase and all of its wonderful benefits without a prescription.* How Does Serretia Work? Taken on an empty stomach, Serrapeptase, a fibrinolytic (fibrin digesting) enzyme, enters the bloodstream via the small intestine. Serrapeptase supports normal fibrin production within the body; its inherent ability to digest waste particles enables the enzyme to support normal recovery times and support healthy circulation.* Why Should I Take Serretia? Serrapeptase has a variety of benefits, and has been found to successfully aid in the breakdown of scar tissue, cysts, blood clots, and plaque. Serrétia may help to improve recovery after sports injuries or surgery, muscle tears and pulls, sinus activity, joint mobility and fluid retention. Like other proteolytic enzymes, Serrapeptase serves as a healthy choice without the risking detrimental effects on various organs, including the liver and kidneys.* Can I Take Too Much Serrapeptase? Although Serretia contains highly potent Serrapeptase, it can safely be incorporated into your supplement regimen. There have been no indications that one can over-dose from the use of systemic enzymes such as Serrapeptase. However, it is important to follow dosaging instructions unless otherwise directed by your healthcare provider.* Is Serretia Enteric Coated? Instead of using any type of enteric-coated serrapeptase, the serrapeptase supplement Serrétia uses a different technology known as Acid Armor. Acid Armor capsules are made of an extra-thick layer of cellulose (the main component of veggie caps). Acid Armor capsules have a better-designed way of fitting the two sides of the capsules together, which limits leaking. Acid Armor capsules have also been designed to delay the release of the capsule's contents for up to an hour. When a product like Serrétia is taken on an empty stomach, the capsule enters and leaves the stomach in 30 minutes or less. This means that the Acid Armor provides more than enough time for the serrapeptase enzyme to get through the stomach and into the more "enzyme friendly" environment of the intestines.* When is the best time to take Serretia? For best results, take the product at least one hour prior to eating and/or two hours after a meal.* Can I take Serrétia with other supplements? Serretia can be used safely with other dietary supplements. In fact, it is recommended that it be taken in conjunction with Neprinol or Syntol for additional proteolytic and fibrinolytic support.* How long does it take for Serretia to work? Although every person is different, some have reported feeling the effects of systemic enzymes in as little as 45 minutes. For therapeutic regimens, the progression may be slow for some and quicker for others. Serrapeptase has been shown to support normal scar tissue formation, normal blood clotting and allows for more fluid and natural blood flow throughout the body. These effects are typically noticed within a very short time frame, though the other benefits of taking Serrétia on a regular basis are boundless and will progress with time.*

Nattovena is the world’s first ultra-concentrated 4,000 FU pure nattokinase dietary supplement, in easy-to-swallow micro-caps. Nattovena contains ultra-refined, pharmaceutical grade, acid stable nattokinase. Nattovena's potency is unparalleled in its class. The standard for nattokinase manufacturing is a potency of up to 2,000 FU’s, or fibrinolytic units, of fibrin degrading activity per capsule. Nattovéna has broken the mold by providing 4,000 FU’s of activity, or double the ordinary dose, offering the strongest nattokinase activity per capsule, period. Nattovena is specifically formulated to address fibrin imbalances in the body. Fibrin is a protein that plays a major role in blood clotting and scar formation, making it an essential component of the healing process and vital for maintaining our health and general well-being. However, fibrin overproduction and impaired fibrin degradation has been implicated in many of today’s most common circulatory health concerns. What is Nattokinase? Nattokinase is a fibrinolytic (fibrin-dissolving) enzyme originally discovered within a Japanese fermented soybean food called natto. The dish consists of soybeans fermented with a strain of Bacillus subtilis bacteria that in turn produce the enzyme, which upon its discovery was later named after the respective dish. The fermented dish, natto, has a slimy texture, sour taste and strong smell that is very unappealing to some. Despite its questionable taste, natto has been shown in numerous studies to have many health benefits. For its use in nutritional supplements, the nattokinase enzyme is extracted and purified in a laboratory setting. Nattovena provides twice the potency of ordinary nattokinase products available and is naturally acid stable in the stomach since it is derived from a food source. This gives Nattovena the added benefit of not having to use an enteric coating or plastic to protect it from stomach acid. Nattovena’s formula contains the highest Fibrinolytic Unit (FU) activity among the major brands of nattokinase supplements, allowing it to hydrolyze 4,000 units of fibrin per capsule, thereby optimizing its cardiovascular benefits and promoting normal blood viscosity. How Does Nattokinase Work? Fibrin is naturally produced in the body by a protein called thrombin and is degraded by the body's own fibrinolytic enzyme, plasmin. Fibrin is typically produced during the recovery and healing processes caused by injury or other health concerns. Usually, these processes exist in a delicate balance; however, many conditions can impair fibrin degradation and lead to excessive levels of fibrin within the body. Nattokinase supplementation can tip the balance back in favor of fibrin removal using two different mechanisms. Firstly, nattokinase is a fibrinolytic enzyme, which means that it can literally dissolve excessive fibrin produced during the healing process. In fact, studies show that nattokinase is actually four times (4x) more potent than the body’s own plasmin in terms of fibrinolytic activity1. Secondly, nattokinase blocks the activity of plasminogen activator inhibitor 1 (PAI-1), which boosts its fibrinolytic capabilities even more. High levels of PAI-1 are directly linked to impaired fibrin degradation and removal, since PAI-1 blocks the body’s natural production of plasmin. By impeding PAI-1, nattokinase promotes the creation of more plasmin from plasminogen (its building block), increasing the amount of natural fibrinolytic enzymes created within the body2. Suggested Use Suggested Use: Take 1 capsule 2 to 3 times daily on an empty stomach. Higher doses may be taken as needed, but it is recommended to not exceed 15 capsules in any 24-hour period unless otherwise directed by a healthcare practitioner. WARNING: Do not take this product without the consent of your physician if you are currently taking blood thinning medications or if you are pregnant or nursing. Frequently Asked Questions What does Nattovena do? Studies have demonstrated that nattokinase improves overall circulation, promotes healthy blood viscosity, promotes healthy clotting factors, keeps blood cells from sticking together, and maintains blood pressure levels already within normal range.* How does it work? Nattovena supports normal clot formation by maintaining normal levels of blood coagulation factors.* It also supports normal clot breakdown by maintaining normal fibrinolytic (clot-dissolving) activity, due to its ability to also increase the production of the body's inherent fibrinolytic enzyme plasmin.* Why is fibrinolytic activity important? Fibrin is a vital protein that forms in response to trauma, injury, or even in cases of autoimmune conditions. The body can not only overproduce fibrin in these instances, but can also produce fibrin when there is no trauma or injury, which can lead to a bevy of unwanted symptoms. Fibrinolytic activity is the body’s natural way of breaking up excessive fibrin and unwanted clots. Is Nattovena safe? Nattokinase is derived from natto, which has been a regular food staple within Asian cuisine for centuries. Although nattokinase has many benefits, studies have shown that it also does not have demonstrative side effects, and the ingredient is considered GRAS (generally recognized as safe) within the US. Does Nattovena have value beyond just heart health? Due to the vast array of unhealthy conditions that excessive fibrin can bring, Nattovena has far greater value than a simple cardiovascular support product. Many aspects of health, from muscle recovery, to immune and joint health are directly related to fibrin and blood viscosity.* Is Nattovena safe to use in combination with prescription blood-thinning drug medication? You should always check with your health care provider prior to taking any new dietary supplements in combination with a prescription. However, Nattovena does not contain any vitamin K, so it is assumed to be compatible with these medications since their mode of action is based on inhibiting vitamin K. Nattovena is not contraindicated with aspirin, natural supplements, or antihypertensive medications although medical supervision when implementing any new supplement regimen is always recommended. Supplement Facts Supplement Facts Serving Size: 1 Capsule Amount Per Serving* % Daily Value Nattovena™ 200 mg † Nattokinase 4,000 FU † * Percent Daily Values based on a 2,000 calorie diet † Daily Value Not Established Other Ingredients: Cellulose (vegetarian Capsules) Keep out of reach of children. Store in a cool, dry place with lid tightly closed.

Syntol Kids Probiotics – Delicious & Effective Gut & Immune Support for Children Syntol Kids Probiotics is a tasty, easy-to-take supplement designed to support your child’s digestive and immune systems. Thanks to the innovative Instamelt Delivery Technology, this formula dissolves instantly without the need for water, making it a hassle-free and enjoyable addition to your child’s daily routine. With a powerful blend of probiotics, prebiotics, and essential vitamins, Syntol Kids works to address common digestive issues while also promoting immune health. Packed with beneficial strains like Lactobacillus rhamnosus GG and Bifidobacterium lactis BL-04, along with Vitamin C and Vitamin D3, Syntol Kids provides complete digestive and immune support for your child's well-being. Why Syntol Kids is Ideal for Your Child: Digestive HealthSyntol Kids contains probiotics that help balance your child's gut microbiome, improving digestion and helping to prevent gastrointestinal issues like diarrhoea and indigestion. Immune System SupportThe clinically studied L. rhamnosus GG strain helps strengthen the immune system, supporting your child’s body against the constant exposure to new germs and bacteria. Easy AdministrationSyntol Kids is formulated with Instamelt Delivery Technology, which ensures the probiotic dissolves instantly without water. This makes it easy and fun for children to take, with a delicious berry flavour they’ll enjoy. A Balance of Probiotics & PrebioticsThe addition of Fructooligosaccharides (FOS) prebiotics provides nourishment for the probiotics, supporting their growth and effectiveness for long-term digestive and immune benefits. Key Features: Delicious Berry-Flavoured Sachets: Your child will love the taste, making supplementation enjoyable and easy. Instamelt Delivery Technology: Dissolves instantly without the need for water, providing a convenient experience. Contains 3 Billion CFUs: Includes Lactobacillus rhamnosus GG and Bifidobacterium lactis BL-04 for effective gut and immune support. Added Vitamins: Vitamin C and Vitamin D3 help boost your child’s immune health. Gluten-Free and Dairy-Free: Safe for sensitive children and those with dietary restrictions. Suggested Use: Maintenance: Take one sachet daily. Increased Support: Take one sachet twice daily, in between meals. To use, simply empty the contents of the sachet directly under your child’s tongue. The great-tasting formula will dissolve instantly, offering effortless consumption. Ingredients: See product label image above. Note: Before using this product, consult a healthcare professional, especially if your child has any medical conditions, is taking medication, or is under the care of a healthcare provider. Keep out of reach of children. Do not exceed the recommended daily dose. This product is not intended to diagnose, treat, cure, or prevent any disease. If any adverse reactions occur, discontinue use and consult your healthcare provider.

Neprofin PET is one of the best joint supplements for pets that is designed specifically to be a natural alternative to provide immune and joint support for household pets. These enzyme pet supplements aim to promote a normal inflammatory response in pets and assist them in pain free movement. Containing a blend of essential enzymes, antioxidants and bioflavonoids that are formulated to help assist movement and support the healing process in household pets. The proteolytic enzymes help to promote a healthy immune system and improve circulatory health in household pets. The antioxidants work by neutralising free radicals, and help protect cells and tissues from damage. They also work to reduce inflammation in your pets. Bioflavonoids which are found in fruits and vegetables, in supplements they provide a range of health benefits. They also help to improve cardiovascular health in your pets and alleviate inflammation. Some Of The Benefits Of Neprofin PET Supplements Are: Reduces inflammation in pets Improves immune health in pets Helps to improve pets’ dental health Assists digestion in pets Improves joint motions in pets Increases pets’ flexibility A supplement for pets that provides blood cleansing Supplement for pets that provides healthy non-degenerative ageing Suitable for any pet that’s suffering from joint pain, injuries or arthritis Improve circulatory health Reduces pain in household pets Reduce swelling in household pets Increase speed recovery from pets who have recently experienced an injury Promote healthy skin conditions in household pets What Are Neprofin PET Supplements Neprofin PET is a supplement for pets that is formulated to support the healthy function of the immune system and the joints in household pets. It can be used as a natural alternative to treating joint problems in dogs and cats as well as improving your pet’s health and longevity. Neprofin PET offers a wide range of health benefits for your household pets including joint support, digestive health, immune system support and many more health benefits. Whether you’ve spotted problems in your pets’ health or you want to prevent any problems from occurring in the future, supplementing Neprofin PET is a great option to add into your pets diet in order to ensure that they’re in good health and help to prevent any future conditions from developing. Neprofin PET is 100% natural, as well as being a non-GMO (Genetically Modified Organism). Regular testing is also conducted in order to determine whether any GMO material is present in the product. Making sure you receive one of the highest quality, and most importantly, natural pet supplements. How Do Neprofin PET Supplements Work Neprofin PET works by supporting the joints in household pets. Containing serrapeptase, a proteolytic enzyme that reduces swelling and speeds up recovery after injury. When taken, serrapeptase works to gently break down proteins that can hinder the health of your pets. This enzyme plays a vital role in supporting joint comfort and mobility in household pets by promoting a balanced inflammatory response, to reduce swelling and improve the overall function of the joints. As one of the best supplements for pets, Neprofin PET also works to improve circulatory health in your household pets. With the use of protease, another proteolytic enzyme that works to digest the excess blood proteins found in their body, which, when given to your pets, is introduced to the blood serum – playing a vital role in blood clotting. This enzyme also works to improve circulatory health and improve the immune system in your pets. Designed to be a natural alternative for joint support for pets; other more well known joint supplements such as glucosamine, chondroitin sulphate and methylsulfonylmethane (MSM) only work by providing lubrication to the joint. Neprofin PET enzymes are a more long term solution for joint discomfort in your pets as they address pain from overuse systemically before it affects the joints. For horses, see the best joint supplements here. How Long Does It Take Neprofin PET Supplements To Work Although every pet is different, depending on things like the size of your animal, some pet owners have reported seeing Neprofin PET supplements work within the first day of adding this supplement to their diet. As every animal is different and varies in size and breed, the speed of which it takes for your pet to experience the benefits will vary, being slow for some animals and faster for others. Normally, supplementing for a month is the minimum recommended amount of time, for noticeable results one to three months will see the best results. For larger animals try Neprofin. Why Neprofin PET Is The Best Joint Supplement For Cats Using Neprofin PET as a joint supplement for cats, will help support your cats joints and overall health and well being. Containing a combination of powerful enzymes, antioxidants and bioflavonoids specifically formulated to help assist movement making it the best joint supplement for cats. Serrapeptase reduces swelling in your feline pet and plays a vital role in speeding up recovery, therefore reducing inflammation. Cats are agile animals, and as they age the excessive stress put on their joints over the years takes a toll. Arthritis is common in older cats, therefore they require more joint support than other pets. With the supplements fast acting nature it ensures quick relief for cats experiencing joint discomfort, allowing them to regain normal joint movement. Neprofin PET is a great option for older cats and active agile felines, working to support their joint function all throughout their lives. Why Neprofin PET Is The Best Joint Supplement For Dogs Taking joint supplements for dogs can provide many benefits for your pet. When dogs experience any form of pain it can be difficult to tell, as they are very good at hiding any signs of illness or discomfort, therefore health problems may go unnoticed. This is the best supplement for dogs as this enzyme prompts regular anti-inflammatory response and will help your pet have pain-free movement. Containing a unique combination of natural anti-inflammatory agents, essential vitamins, and joint supporting compounds that work together to alleviate pain in dogs. This enzyme relieves pain by reducing inflammation and supporting cartilage repair, which helps to treat any joint pain your dog may be experiencing. What makes Neprofin PET the best joint supplement for dogs is its fast-acting nature, with some people reporting seeing benefits within one day of implementing this supplement in their dogs diet, therefore providing quick relief for dogs who are suffering from joint discomfort. This enzyme is beneficial for older dogs who’ve experienced wear a tear on their joints over the years, and experience joint pain from their lifestyle and other factors such as ageing, and need that extra support. However, younger athletic dogs who are regularly active will also benefit from taking Neprofin PET, as their lifestyle requires more joint support, therefore this enzyme will help maintain normal joint function and mobility. Helping to enhance joint health and restoring vitality in dogs, this enzyme is the best joint supplement for dogs. How Do I Know If My Dog Needs Supplements? It can be difficult to know whether your dog needs to take Neprofin PET, as dogs are generally good at hiding their pain and discomfort from their owners. However, there are certain signs to look out for that could indicate that your pet is in need of some extra support. One sign to look out for is if you start to notice your dog experiencing joint stiffness or physical discomfort after playing. This could be a sign that their joints are playing up and may need some support. Another sign that your dog would benefit from taking Neprofin PET is if you’ve noticed that their health has started to decline. This could be due to lifestyle or ageing, and could mean that your dog needs some extra support. With the addition of Neprofin PET to your dogs diet, this can help them live a long, happy and pain free life. Noticing signs of ageing from slower movements, frequent napping or shorter playtime can cause pet owners to be concerned with worry. That’s why it’s important to spot these signs early, so you can make the healthy decision for your pet. Do Dogs Need Joint Supplements? Neprofin PET can be extremely beneficial to dogs experiencing joint issues or at risk of developing them. As dogs age, they are more prone to developing health conditions, such as arthritis, hip dysplasia, and joint inflammation. Did you know that 1 in 5 dogs will experience arthritis in their lifetime? Larger breeds are also more at risk of developing this health problem as their excessive weight puts more stress on their joints than smaller breeds. By taking Neprofin PET it will treat the pain in your dog before it reaches their joints, making it a more effective supplement than other options that only work to lubricate the joints. Therefore, taking Neprofin PET is a long term solution for your dogs suffering from joint problems. Application: For optimal results of Neprofin PET the dosage should be determined by your pet’s size and needs by the recommended dosage chart, or with guidance from your veterinarian. For small pets under 5 lbs add ¼ – ½ scoop to wet or dry food 1-2 times daily, or for animals weighing between 6 – 25 lbs add ½ – 1 scoop. If your pet weighs 26-75 lbs add 1-2 scoops to their food mixture 2-3 times a day. For larger pets that weigh 76-150 lbs add 2-3 scoops 2-4 times daily.